Why Isn’t My Melatonin Putting Me To Sleep?

Why Isn't My Melatonin Putting Me To Sleep
Beside Melatonin, Many solutions are available to improve your sleep quality and duration, such as meditation, yoga, exercise, and combining with Valerian and GABA supplements if necessary.

Melatonin is a hormone produced in the brain that helps regulate our sleep-wake cycle and circadian rhythm, affecting when we sleep and wake up. 

Melatonin has become popular because it has been shown to help people with insomnia, shift work disorder, jet lag, or other sleeping problems.

Melatonin is not a sleeping pill; it is more than that regulates Mitochondrial Health, inflammation, and other things. 

However, Some people who take Melatonin find that it does not work for sleep. 

In this article, we will explain What to Do When Melatonin Does not Work For you? and “How Can Make you Boost the Effectiveness Of Melatonin.”

Why Isn’t My Melatonin Putting Me To Sleep?

Melatonin supplements are not a cure-all for sleep problems, and Melatonin supplements might help some people fall asleep faster, but it does guarantee. 

When you fall asleep, melatonin levels rise to signal your body that it is time to sleep. When you wake up, melatonin levels drop to signal that it’s time to be alert and active again.

With age, melatonin production decreases, which is why older adults often have more difficulty sleeping than younger adults.

Yet, our body metabolizes Melatonin as well as other factors such different person to person. Beside, EMF and Blue-light exposure also negatively affect on Melatonin secretion. 

The Most Common Reason People Can’t Fall asleep is:

  • GABA Dysregulation (Study showed that Brain GABA Dysregulation in Primary Insomnia)
  • Overactive Amygdala (The amygdala modulates brainstem arousal and sleep centers.)
  • Stimulates(CaffeineGuarana)
  • Exercise Before Sleep

Study found that amygdala activation reduced after a night of sleep and that this diminished was proportional to the duration of REM sleep.

You Might Not Have Melatonin Deficiency

Another reason has difficulty sleeping because of Glutamate toxicity.

Glutamate is involved in transmitting nerve signals in the brain and other parts of the nervous system.

However, people with excessive Glutamate tend to “overthink” because when they try to focus on one thing, their neurons are constantly firing and releasing Glutamate. This might lead to paranoia, anxiety, and insomnia.

Relationship Between GABA Deficiency And Glutamate 

The neurotransmitter GABA in the brain can help you sleep better and be calmer, and the opposite effect of Glutamate regulates the activity of other neurotransmitters

This is why it is important to find ways to increase your GABA levels for better sleep. 

GABA deficiency can lead to glutamate excitotoxicity, a condition where glutamate molecules cause excessive stimulation of neurons and nerve cells, leading to cell death.

Popular sleep supplements such as Valerian Roots and GABA or active form B6 supplements can be more helpful for sleep if you have GABA deficiency. 

Without enough GABA, you can find yourself overthinking, anxious, and stressed, which leads to sleep problems.

Avoid Caffeine For Better Sleep And GABA

Caffeine is a stimulant that stimulates or speeds up central nervous system activation.

Some people are more sensitive to Caffeine than others. 

Caffeine has also been shown to reduce inhibitory (GABAergic) action, which in turn causes increased stress and anxiety. 

For that reason, minimizing Caffeine intake or switch Decaffeinated Coffee is better to choose people who have anxiety and insomnia. 

Related: Does Melatonin Counteract Caffeine?

The Things Helps For Effectiveness Of Melatonin

The stress hormone “Cortisol” can inhibit the production of Serotonin, Melatonin, and GABA; they’re all important for better sleep. 

Stress can cause Amygdala (fear center) will become overactive and suppress the hippocampus area, which is responsible for memory, learning, and emotion regulation. For that reason, working on the Cortisol level is the Number one thing if you want melatonin to work better.

Recent research has shown that people experiencing chronic stress and insomnia show changes in their amygdala. Specifically, these changes include increases in gray matter volume and size of the right amygdala, which is responsible for fear-related memories.

However, long-term meditation and stress management skills showed that a reduced amygdala and better control for sleeplessness and negative thoughts eventually lead to better sleep.

That is why working on your stress and combine with Melatonin is a far better approach for every person.

Things Help Ease Stress:

  • Magnesium, B6, B1, Vitamin C, and D
  • Adaptogens (Rhodiola Rosea, Ashwagandha, Korean Ginseng)
  • Meditation (Mindfulness)
  • Cognitive Behavior Therapy
  • Wim Hof Breathing Techniques
  • Progressive Muscle Relaxation

What Helps Melatonin Work Faster?

Exposure to blue and green light in the evening can inhibit melatonin production, leading to disrupted sleep cycles. This happens when there is too much light at night. So, avoiding blue light at night and stress management through meditation and breathing can help melatonin work faster and more effectively. 

Melatonin Supplements Form Matter

Some people may prefer a time-release capsule or an oral spray. These forms are absorbed more slowly and can be taken at bedtime for the desired effect.

Start with a small dosage, and see if it works. 

What Can I Take For Sleep If Melatonin Doesn’t Work?

If Melatonin doesn’t seem to be working for you, there are many other ways to help with your sleep, including those you can take without a prescription. The following are some examples of over-the-counter medications that you could try:

  • Valerian root (GABA receptors)
  • L-Theanine (Alpha Brain Waves and Works With GABA)
  • 5-HTP (Precursor of Melatonin)
  • Kava Kava (GABA Receptor)
  • Magnesium Plus B6 (GABA and Serotonin)

Related: Can Melatonin Supplements Make You Anxious?


Don’t be discouraged if you decide to use Melatonin and it doesn’t help you sleep. 

There are many reasons why this might happen. The first step is to determine the cause of your sleep difficulties and work on managing that. 

If you have tried different doses of Melatonin and still can’t sleep, try reducing caffeine intake and optimizing stress management skills by Meditation and Breathing as well as changing the diet to Magnesium Rich foods.

I hope this articles answer your questions.

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