Melatonin Supplements: Can They Make You Nervous?

melatonin supplement
Melatonin’s full name is N-acetyl-5-methoxy-tryptamine.

As we know, Melatonin is the sleep hormone responsible for regulating the sleep circle. But people are afraid that “taking hormones as a supplement is dangerous, right?” 

Long before, thanks to technology, people could not find that “hormone supplement.” we found. This kind of thing gave us certain advantages, and the hormones are mostly used by people with some deficiency or problems. (Like Testosterone, Insulin, And Thyroids)

I can say “Hormone supplement” is not always the “best choice,” but sometimes it can be. And even, it might be a better option for deficiency.

In this article, we will discuss whether taking “Can Melatonin Cause Anxiety?” and “Can Melatonin Make You Nervous?

Can Melatonin Help With Anxiety And Nervous?

Anxiety is a natural stress response, and the symptoms might be different people to person. Underlying reason anxiety might be hormonal imbalance, cognitive distortions, or environmental or cultural factors.

However, culture or not, too much anxiety can be detrimental to our quality of life. There are certain things that help you get reduce anxiety attacks and support your well-being. Deep Quality Sleep, on the other hand, is supported by science showing that it reduces anxiety attacks, improves Serotonin, Dopamine, and other brain chemicals, balances insulin (when you can’t sleep, you will experience more hunger), and support mitochondrial health.(regulate inflammation)

For that, Melatonin certainly works to help better sleep. So, Melatonin, on the other hand, directly affects your well-being. 

Lack of Melatonin can cause sleep disturbance, and it leads to anxiety, an overactive amygdala(fear center), difficulty in concentration, and mitochondrial problems. 

Another thing you should know about Melatonin is:

  • According to the research, the hormone melatonin may help alleviate anxiety symptoms by reducing activating the amygdala. 
  • High cortisol may cause hippocampus atrophy, which is “bad” for the HPA axis and cause an overactive amygdala. (fear center) Research showed that melatonin administration led to a reduced cortisol response as well as improved inflammation markets. 
  • The study found that Melatonin can help anxiety, sleep, and circadian rhythm disorders. Also, Melatonin is first-line therapy for people over 55 with insomnia, parasomnia, and circadian rhythm sleep disorders.

 If you can’t sleep enough, you will feel in a far more dangerous state depressed state, dizziness, anxiety, binge-eating, and mitochondrial and immune problems. 

Optimizing Melatonin is certainly worth for if you experience Sleep deprivation or insomnia. 

For more information: Why Is Melatonin Important For Well-Being, Anxiety, And Depression?

The circadian system affects mood, anxiety, and motivated behaviors through local clock gene expression and indirect links from the suprachiasmatic nucleus (SCN).

Hippocampus Crucial When It Comes To Anxiety

The limbic system’s hippocampus regulates learning, memory storage, and spatial navigation. Also, The hippocampus has gained significant attention in mood disorders research. There are some kinds of things you can stimulate the Hippocampus called “Fasting,” but if you have anxiety, long-term fasting isn’t the best strategy.

Exercise, on the other hand, can also stimulate the “Hippocampus” that creates new brain cells and neurogenesis.

Although not completely responsible for anxiety and depression symptoms, some theories suggest that the hippocampus shrank when an individual has depression and anxiety. But, besides fasting and exercise.

Did you know that good quality sleep as well as melatonin can help to Hippocampus?

Melatonin Protects Hippocampus From Damages 

This is unique because the protection hippocampus is vital for neurogenesis and brain health. However, certain kinds of things, such as beta-amyloid, can directly impact neurogenesis( the process by which new neurons are formed in the brain) and our mood. 

The problem is that the accumulation of neurotoxic beta-amyloid plaques is critical in the development of Alzheimer’s disease. Not just as beta-amyloids might have crucial roles when it comes to anxiety and depression. 

Anyone who experiences Alzheimer’s tends to have anxiety, depression as well as other problems because lack of oxygen and accumulative neurotoxic beta-amyloid leads to cause anxiety and even panic.

To prevent this, optimizing Melatonin (for sleep) might be helpful. Besides Melatonin, Physical Exercises, Meditation, and Omega-3 (Especially Krill’s), some herbs such as Gingko Biloba and Turmeric, Fasting, and Ketones can help to heal  Hippocampus damage.

 Increased anxiety and depressive symptoms are related to hight levels of amyloid beta may be associated with symptoms of anxiety in these individuals

Deep Sleep Can Lower Anxiety, Right?

Yes. if it isn’t, lack of sleep worsens Anxiety and Panic.

For my opinion, one of the most crucial factors for lowering anxiety, depression as well as stress is deep quality sleep. This is because Melatonin, likewise, helps you get to regulate the brain waves (Theta, Alpha, And Delta) and reduce anxiety.

As we discussed before, high-quality deep sleep can help to improve men’s hormones such as testosterone and women well being. Now, you start to understand the “puzzle.” Testosterone? Omg.

Insufficient testosterone causes low libido, body and facial hair loss, difficulty concentrating, depression, anxiety, sleep problems, and irritability.

  • Low testosterone levels have been associated with sleep deficiency and severe sleep apnea. Total sleep time influences morning testosterone levels in older men. (source)
  • The effects of sleep loss on testosterone levels were clear. Male testosterone levels dropped by 10–15% after five hours of sleep. This shows that sleep is directly correlated to testosterone levels.

As you can see, optimizing Melatonin for helping testosterone and leads to better libido and mood. 

More information: Can Testosterone Hormone Effect Sleep Quality? 

You can optimize your melatonin production via using tryptophan amino acid; Magnesium, Zinc, and B6 are precursors to a number of essential compounds, including GABA, Serotonin, and Melatonin.

The Inflammation-Anxiety Connection

Another interesting area is the inflammation and anxiety connection. As before, we thought that inflammation is something that is separated from our mood and anxiety. Sorry, it changed.

According to the research, people with chronic inflammation are more likely to experience anxiety and depression.

Earlier meta-analyses have shown that depressive states are associated with elevated levels of proinflammatory cytokines such as tumor necrosis factor (TNF), as well as IL-6.

Inflammation also causes mitochondrial problems and dysfunctions. Yet, if you don’t know that meaning, you should because mitochondrial dysfunctions can also lead to anxiety as well as aging. 

The logic behind that once mitochondria can’t work (because of inflammation), your brain tends to crave more of the ATP, or energy. 

Especially our brain uses most of the ATP energy and uses that ATP for mood regulation.

But don’t worry, for reducing inflammation, “dry fasting” is the best method. Plus, I have a very good guide for optimizing mitochondria without the expense or anything special. I wrote it for that who are living in other countries who can’t afford all of the “organic” things.

Here is the check: Free Alternative For Optimizing Mitochondria, And Longevity.

To Fighting Anxiety, You Need TO Balance GABA

Optimizing, enhancing, and healing our circadian rhythm is one methods of fighting anxiety and depression. But it’s another thing you should consider that: “GABA” (Gamma-Aminobutyric Acid)

GABA and glutamate are the most abundant neurotransmitters in the brain and are involved in controlling alertness, anxiety, muscular tension, and memory processes.  

GABA lowers the amount of excitement in the brain; you can feel calmer and relaxed, and you probably know how it feels to change that. Most Anti-anxiety drugs improve GABA and stop glutamate from doing its job.

Anyway, Excessive amounts of glutamate can produce excitotoxicity, which harms nerve cells, and certain brain area can cause anxiety, even obsession thoughts, and makes overthinking.

To prevent this, avoiding using excess caffeine makes you feel more alert because it can increase glutamate activity and block GABA from being released.

More information: Relaxing and Focusing: GABA and Glutamate in the Human Brain

Limit Amount of Flouride Exposure For Optimal Pineal Gland

People are becoming more aware of the toxic chemical exposure from the environment, foods, and mental amalgams that can disturb health.

According to National Research Council research, fluoride will undoubtedly affect pineal gland function and reduce melatonin synthesis, which might have a number of repercussions on people.

Excess Flouride could damage the pineal gland(Melatonin is the only known hormone synthesized by the pineal gland, and DMT(Soul hormone)

Limit the amount of fluoride you expose for the optimum pineal gland.

Also, fluoride can disturb neurotransmitters such as (dopamine and serotonin) and the thyroid. Why?

 Excess fluoride can bind to the iodine and leads to iodine deficiency.

Blue Light Can Be Detrimental and Cause Anxiety

Many types of cancer, diabetes, obesity, heart disease, and Alzheimer’s are associated with blue light exposure at night and circadian disruption.

If you suppress melatonin release at night due to blue light, you will inhibit growth hormone, making it more difficult to burn fat and build muscle, and you will also hinder the brain from cleaning out toxins such as beta-amyloid, tau, and heavy metals collected throughout the day.

Some toxins and proteins, such as beta-amyloids, have been linked to Alzheimer’s and Parkinson’s disease, as well as an anxiety disorder. 

What If Melatonin Supplement Can Cause Anxiety?

Melatonin is generally safe, but using it in high amounts can cause temporary and short-lasting anxiety as a side effect.

It is more beneficial to start with low amounts, such as 0.3 to 1 mg of Melatonin. 

Actually, Melatonin can activate sirtuins and has anti-aging effects; also, the lack of Melatonin is a more serious problem when it comes to anxiety and depression.

Don’t Excessive Fasting For Circadian Rhythms

I’m a big fan of Dry Fasting because Fasting promotes the diversity and dynamics of the microbiome, activating sirtuins genes and promoting autophagy and longevity.

Fasting is also the healthiest and easiest way to reverse obesity which is determined by the feeding and fasting cycles of the host. 

But fasting and eating at night may disrupt your sleep. Certain bacteria, such as “Enterobacter aerogenes,” are sensitive to Melatonin which affects circadian rhythms. 

Circadian rhythm disturbance can alter the microbiota and thus have a detrimental impact on metabolic health. That is why it is critical not to overeat at night.

Avoid Pornography Or Sexual Especially At Night

When you watch binge porn, the brain secrets dopamine; Dopamine is a neurotransmitter that affects mood, motivation, and reward-driven behavior. 

brain reward center
Dopamine reward system and porn 

The main reason porn is addictive is that it highjacks the reproduction system. It floods the brain with dopamine, which creates a sensation of ecstasy. The problem is that the excess dopamine causes desensitization and a constant desire to seek novelty.

Regardless, the more dopamine in your system from coming stimulants such as pornography, drugs, and sugar, the more you have difficulty sleeping because overactive dopamine suppresses serotonin, which eventually reduces Melatonin. 

On the other hand, Porn addiction can trigger anxiety via the stimulation of dopamine receptors, making us overexcited. 

For standard and social health, avoid pornography as much as you can.

Related: Porn Addiction Dangers: What You Need to Know


Supplementing and, depending are the hormones, are not the best strategies when it comes to managing anxiety. 

However, there are certain things we are sure that without enough sleep, you will experience far more dangerous symptoms.

The best things for optimizing melatonin production are eating serotonin, B6, and Magnesium rich foods, getting enough sunlight, avoiding fluoride exposure, and limiting blue-light exposure at night. 

Also, limit your EMF exposure because electromagnetic fields above certain levels can trigger biological effects that cause insomnia and other unpleasant problems. 

My Opinion: Don’t Feel Alone!

If you suffer anxiety and panic attacks, relax that feeling and try to find “what is the main cause that i feel that?”. 

Simple things such as nutritional deficiency, low levels of serotonin, and methylation problems might worsen anxiety symptoms. 

Once you identify the problems, start with small steps to solve that. 

Also, there are tons of tools for managing anxiety without medicine. In my opinion, the best strategies are:

  • Regular Inner-smile Meditation (8 weeks at least)
  • Self Hypnosis (21 days at least)
  • Cognitive Behavior Therapy(Science Based, Easy to Follow, and It Helps Cultivate Philosophy)
  • Optimizing Magnesium Plus B6 ( B6 Helps regulate GABA, Serotonin, And Dopamine)
  • Using Adaptogens
  • Wim Hof Breathing (activating brain areas, the insula, and the anterior cingulate cortex, Reducing inflammation of IL-6 )

Thank You!

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