Xanax And Melatonin: Can I Take A Together?

can i take a melatonin with xanax
Studies have also found that Melatonin can be an effective treatment for insomnia in children.

Melatonin supplements, available over-the-counter without a prescription, are often used for insomnia and sleep enhancement.

Xanax, or alprazolam, is a benzodiazepine prescribed for anxiety and panic disorders. Some people use Xanax as a sleep aid, but it’s not a prescribed sleeping pill.

If used correctly, especially regarding dosage, Melatonin and Xanax can be taken safely together. However, combining these two drugs can increase the risk of side effects like sedation, dizziness, and next-day sleepiness if not appropriately used.

Let’s Dive Into it.

How Do Xanax And Melatonin Differ in Terms of Their Uses, Risks, And Potential Considerations?

Let’s check some of the different aspects of Melatonin and Xanax together.

SubstanceDescriptionPotential UsesRisks/Considerations
XanaxXanax is a prescription medication used to treat anxiety and panic disorders. It belongs to a class of drugs called “benzodiazepines.” and the active ingredient is “Alprazolam.”Xanax can be used to reduce symptoms of anxiety(overthinking) and promote relaxation. It may also be used to treat insomnia.Xanax is a powerful benzodiazepine medication that is commonly prescribed for the treatment of anxiety and panic disorders. While it can be effective in reducing symptoms of anxiety and promoting relaxation, it is important to be aware of its potential for addiction(which needs to be aware) and the risks it may pose.
MelatoninMelatonin is a hormone, and it’s available as a dietary supplement.Melatonin is useful for insomnia. It may also have other potential health benefits, such as high antioxidant activity and immune system support.Melatonin is generally considered safe and non-addictive. But there is not that much research available long term usage. Yet, it may cause side effects in some people as well as may interact with certain medications to promote drowsiness.

Xanax Could Helps You Get Better Sleep

Xanax belongs to the benzodiazepines group, sedative-hypnotic agents affecting the central nervous system. They enhance the effects of GABA neurotransmitters, reducing anxiety by slowing nerve transmissions in the brain.

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For those with anxiety disorders, Xanax can be beneficial. Individuals can remain calmer in stressful situations by slowing down the brain’s nerve transmissions.

Is Xanax better for sleep or anxiety?

Xanax can be used for anxiety and insomnia, but it is not an insomnia cure or sleep pill. For some people, Xanax may be more helpful in reducing anxiety, while others may find that it helps them more with their sleep problems.

Careful About GABA Deficiency & Dysregulation

Melatonin is a hormone stronger and hormones stronger messenger than vitamins, minerals, and proteins. 

However, some people have the right amount of Melatonin, but it still can’t calm down and can’t sleep because of a dysregulated GABA receptor. 

FactorDescriptionImpact on Sleep
GABA deficiencyGABA works in conjunction with another neurotransmitter, glutamate, to balance the excitatory and inhibitory signals in the brain.GABA deficiency can interfere with sleep quality and duration.
Melatonin deficiencyMelatonin is a hormone that helps regulate the sleep-wake cycle. A deficiency of melatonin can lead to sleep problems, such as difficulty falling asleep, staying asleep, and achieving deep sleep.Melatonin deficiency can interfere with sleep quality and duration.

GABA dysregulation is linked to insomnia and sleep disorders. Addressing GABA levels might be necessary if you struggle to sleep even when using melatonin.

This is why people may feel sleepy after taking Xanax. While Xanax isn’t a sleeping pill, it can help individuals fall asleep more quickly and stay asleep throughout the night.

Use Two Of Them If Required

Taking Xanax and melatonin together has certain risks, including sedation, which may cause drowsiness and dizziness.

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Benzodiazepines are typically used to help people relax, reduce anxiety, and promote sleep. Combining them with melatonin can shorten the time it takes to fall asleep, and a high dosage of both melatonin and Xanax may lead to increased sleep length and duration.

However, there may be times when you need melatonin to enhance sleep quality and improve overall health and mitochondrial function. In these cases, it’s best to take the lowest possible melatonin dosage, such as 0.3, 0.5, or 1 mg, to prevent side effects.

If you struggle with insomnia, this combination may be effective. Unlike Xanax, melatonin does not have withdrawal symptoms after discontinuing its use.

Optimize Melatonin Natural Ways For Preventing Side Effects

The best way to avoid side effects is by combining these; you can naturally increase Melatonin production through simple strategies such as:

  • Avoid bright lights before bedtime: One of the best ways to naturally increase melatonin levels is by avoiding bright lights before bedtime. This includes TV screens, computers, and smartphones.
  • Exercise: Another way to naturally increase melatonin levels is by exercising for at least 30 minutes daily. This helps your body produce more serotonin which in turn increases your body’s production of Melatonin.
  • Use blue light-blocking glasses: Using blue light-blocking glasses can help you avoid the effects of exposure to blue light, which can disrupt sleep patterns and suppress melatonin production.
  • Reduce EMF Exposure: A study showed that EMF exposure affects the pineal gland, suppressing melatonin production.

Related: EMF And Anxiety Relationship: Does EMF Change How We Feel?

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Methods For Optimize GABA Levels Without Drug

Xanax work by enhancing the effects of the neurotransmitter GABA. However, there are certain risks when times to cutting Xanax, such as withdrawal symptoms and feeling anxiety, and mood problems. To prevent this, you can use some of the strategies for enhancing GABA receptors, such as:

  • Meditation: A study found that people who practiced meditation for eight weeks had increased GABA levels. Another study found that people who took a class in mindfulness experienced decreased anxiety and depression symptoms. Yoga, tai chi, qigong, and other gentle exercises increase GABA levels by reducing stress hormones like cortisol.
  • Ketones: Ketones are usually associated with ketogenic diets, but they can also be produced by the liver when you have high levels of acetoacetate. There is a lot of speculation about how ketones affect GABA (gamma-aminobutyric acid). The theory is that ketones increase GABA by increasing the activity of its receptors and new brain cell formation (BDNF protein), which boosts mood and well-being.
  • Optimize Vitamin Intake: Magnesium. Zinc, Vitamin B6, and Taurine are good for that. However, choosing the Magnesium Acetyl Taurate can cross the blood-brain barrier and enhance relaxation. 
  • Limit Caffeine: The problem is that Caffeine lowers GABA, and the research found that Caffeine has been found to suppress the inhibitory (GABAergic) activity and modulate GABA receptors,

Can I Take Melatonin with anxiety meds?

Always try to optimize Melatonin in natural ways. However, taking Melatonin with anxiety medications is not advisable as these medications are sedatives, so the combination might make you too sleepy and cause drowsiness the next day. If necessary, try to use the smallest dosage, Melatonin, such as 0.3 mg, before sleep to prevent drowsiness. 

Is 10 mg of Melatonin Too Much For Sleep?

Often, people don’t require large amounts of melatonin for sleep. However, under specific circumstances, such as immune issues or antioxidant support, individuals may use 10mg of melatonin for short periods with higher dosages.

DosagePotential Effectiveness
0.5 mgIt may be effective for some individuals, with lesser side effects than the other dosage. However, sometimes it may be too low for others.
3 mgIt may be effective for many individuals for a first weeks. However, it might have to side affect more than 0,5 or micro dosage of melatonin.
10 mgIt might help you increase plasma Melatonin levels for antioxidant properties more than others and a faster period. However, It may be but may be too high for others and could potentially lead to side effects. 10 mg can be used for specific issues with immunity or for advance
sleep problems.

What meds cannot take with Melatonin?

  • Diabetes medications: (Talk to a doctor because it might affect blood sugar)
  • Fluvoxamine (Luvox): Obsessive-Compulsive disorder drugs can increase Melatonin plasma and, if combined with a Melatonin supplement, can cause excessive drowsiness. 
  • Seizure threshold lowering drugs


Melatonin is a remarkable hormone and supplement, not only because it helps manage anxiety and depression by supporting the secretion of brain chemicals but also because it enhances mitochondrial function and slows down the aging process.

A melatonin deficiency can be pretty harmful, leading to mitochondrial damage, increased cancer risk, suppressed new brain cell production, and reduced thyroid function (which can ultimately result in mood disorders).

In certain situations, such as jet lag or shift work disorder, it’s difficult to control our environments and maintain optimal melatonin levels. In these cases, supplementing with the smallest possible dosage can help prevent side effects and maintain overall health.

Note: Always consult a doctor before using any supplements with Xanax.

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