Xanax And Melatonin: Can I Take A Together?

can i take a melatonin with xanax
Studies have also found that Melatonin can be an effective treatment for insomnia in children.

Melatonin supplements are available over-the-counter and can be purchased without a prescription, and people are using it for insomnia and to enhance sleep. 

Xanax, also known as alprazolam, is a benzodiazepine prescribed for anxiety and panic disorders and some people use Xanax as a sleeping aid, but it’s not prescribed sleep pills. 

Both Melatonin and Xanax are safe to take together if used correctly. (especially dosage), but if not, taking these two drugs together can increase the risk of side effects like sedation, dizziness, and next-day sleepiness.

Let’s Dive Into it.

How Do Xanax And Melatonin Differ in Terms of Their Uses, Risks, And Potential Considerations?

Let’s check some of the different aspects of Melatonin and Xanax together.

SubstanceDescriptionPotential UsesRisks/Considerations
XanaxXanax is a prescription medication used to treat anxiety and panic disorders. It belongs to a class of drugs called “benzodiazepines.” and the active ingredient is “Alprazolam.”Xanax can be used to reduce symptoms of anxiety(overthinking) and promote relaxation. It may also be used to treat insomnia.Xanax is a powerful benzodiazepine medication that is commonly prescribed for the treatment of anxiety and panic disorders. While it can be effective in reducing symptoms of anxiety and promoting relaxation, it is important to be aware of its potential for addiction(which needs to be aware) and the risks it may pose.
MelatoninMelatonin is a hormone, and it’s available as a dietary supplement. Melatonin is useful for insomnia. It may also have other potential health benefits, such as high antioxidant activity and immune system support.Melatonin is generally considered safe and non-addictive. But there is not that much research available long term usage. Yet, it may cause side effects in some people as well as may interact with certain medications to promote drowsiness.

Xanax Could Helps You Get Better Sleep

Xanax Belongs to Benzodiazepines, and Benzodiazepines are sedative-hypnotic agents that act on the central nervous system, enhancing the effects of GABA neurotransmitters. This reduces anxiety by slowing down nerve transmissions in the brain.

Xanax greatly helps people who suffer from anxiety disorders. They can remain calmer in a particularly stressful situation by slowing down your brain’s nerve transmissions.

Is Xanax better for sleep or anxiety?

Xanax can be used for anxiety and insomnia, but it is not an insomnia cure or sleep pill. For some people, Xanax may be more helpful in reducing anxiety, while others may find that it helps them more with their sleep problems.

Careful About GABA Deficiency & Dysregulation

Melatonin is a hormone stronger and hormones stronger messenger than vitamins, minerals, and proteins. 

However, some people have the right amount of Melatonin, but it still can’t calm down and can’t sleep because of a dysregulated GABA receptor. 

FactorDescriptionImpact on Sleep
GABA deficiencyGABA works in conjunction with another neurotransmitter, glutamate, to balance the excitatory and inhibitory signals in the brain.GABA deficiency can interfere with sleep quality and duration.
Melatonin deficiencyMelatonin is a hormone that helps regulate the sleep-wake cycle. A deficiency of melatonin can lead to sleep problems, such as difficulty falling asleep, staying asleep, and achieving deep sleep.Melatonin deficiency can interfere with sleep quality and duration.

For that, GABA dysregulation is associated with insomnia and sleep disorders. If you can’t sleep even using Melatonin, you might need to address GABA.

That is why people experience “sleepy” after taking Xanax. (Xanax isn’t a sleeping pill) but it can make them fall asleep more quickly and stay asleep throughout the night.

Use Two Of Them If Required

There are certain risks associated with taking Xanax and Melatonin together. These risks include sedation, which can cause drowsiness and dizziness.

Benzodiazepines are generally used to help people relax, reduce anxiety, and promote sleep. Combining with Melatonin reduces to time to fall asleep, and a high dosage of Melatonin and Xanax makes you feel yawning and increase sleep length and duration.

However, at certain times you might need to use Melatonin to enhance the quality of sleep as well as improve Health and mitochondria. For that reason, take Melatonin’s lowest dosage possible such as 0.3, 0.5, or 1 mg, which prevents side effects.

 If you have insomnia, this will work. Unless Xanax, Melatonin has no withdrawal symptoms after stopping use. 

Optimize Melatonin Natural Ways For Preventing Side Effects

The best way to avoid side effects is by combining these; you can naturally increase Melatonin production through simple strategies such as:

  • Avoid bright lights before bedtime: One of the best ways to naturally increase melatonin levels is by avoiding bright lights before bedtime. This includes TV screens, computers, and smartphones.
  • Exercise: Another way to naturally increase melatonin levels is by exercising for at least 30 minutes daily. This helps your body produce more serotonin which in turn increases your body’s production of Melatonin.
  • Use blue light-blocking glasses: Using blue light-blocking glasses can help you avoid the effects of exposure to blue light, which can disrupt sleep patterns and suppress melatonin production.
  • Reduce EMF Exposure: A study showed that EMF exposure affects the pineal gland, suppressing melatonin production.

Related: EMF And Anxiety Relationship: Does EMF Change How We Feel?

Methods For Optimize GABA Levels Without Drug

Xanax work by enhancing the effects of the neurotransmitter GABA. However, there are certain risks when times to cutting Xanax, such as withdrawal symptoms and feeling anxiety, and mood problems. To prevent this, you can use some of the strategies for enhancing GABA receptors, such as:

  • Meditation: A study found that people who practiced meditation for eight weeks had increased GABA levels. Another study found that people who took a class in mindfulness experienced decreased anxiety and depression symptoms. Yoga, tai chi, qigong, and other gentle exercises increase GABA levels by reducing stress hormones like cortisol.
  • Ketones: Ketones are usually associated with ketogenic diets, but they can also be produced by the liver when you have high levels of acetoacetate. There is a lot of speculation about how ketones affect GABA (gamma-aminobutyric acid). The theory is that ketones increase GABA by increasing the activity of its receptors and new brain cell formation (BDNF protein), which boosts mood and well-being.
  • Optimize Vitamin Intake: Magnesium. Zinc, Vitamin B6, and Taurine are good for that. However, choosing the Magnesium Acetyl Taurate can cross the blood-brain barrier and enhance relaxation. 
  • Limit Caffeine: The problem is that Caffeine lowers GABA, and the research found that Caffeine has been found to suppress the inhibitory (GABAergic) activity and modulate GABA receptors,

Can I Take Melatonin with anxiety meds?

Always try to optimize Melatonin in natural ways. However, taking Melatonin with anxiety medications is not advisable as these medications are sedatives, so the combination might make you too sleepy and cause drowsiness the next day. If necessary, try to use the smallest dosage, Melatonin, such as 0.3 mg, before sleep to prevent drowsiness. 

Is 10 mg of Melatonin Too Much For Sleep?

Most of the time, people don’t need that amount of Melatonin for Sleep. However, in certain conditions, such as immune problems and antioxidant support, people use 10mg of Melatonin for a short periods of high dosages.

DosagePotential Effectiveness
0.5 mgIt may be effective for some individuals, and lesser side effects compare to the other dosage. However, sometimes it may be too low for others.
3 mgIt may be effective for many individuals for a first weeks. However, it might have to side affect more than 0,5 or micro dosage of melatonin.
10 mgIt might help you increase plasma Melatonin levels for antioxidant properties more than others and a faster period. However, It may be but may be too high for others and could potentially lead to side effects. 10 mg can be used for specific issues with immunity or for advance
sleep problems.

What meds cannot take with Melatonin?

  • Diabetes medications: (Talk to a doctor because it might affect blood sugar)
  • Fluvoxamine (Luvox): Obsessive-Compulsive disorder drugs can increase Melatonin plasma and, if combined with a Melatonin supplement, can cause excessive drowsiness. 
  • Seizure threshold lowering drugs


Melatonin is my favorite hormone, as well as a supplement. Why? Because it does not just help manage anxiety and depression(via helping secreted brain chemicals) but also helps mitochondrial functions and slows down the aging process.

Melatonin deficiency is far more dangerous, and it will cause mitochondrial damage, increase the risk of cancer, suppress new brain cell production, and reduce thyroid functions(eventually causing mood disorder.)

Sometimes we can’t control our environments(jet lag, shift work disorder), and we need to optimize Melatonin levels with supplements. Therefore, you can take the smallest dosage possible to prevent side effects. 

Note: Always consult a doctor before using any supplements with Xanax.

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